Targeting the Imbalanced Immune Response in COVID-19

8 min read

Too much histamine or prostaglandin D2 signaling or too little interferon signaling lead to increased risk for severe COVID-19. An imbalanced immune response appears to be the key to whether a person develops severe COVID-19 with pneumonia and other complications such as coagulopathy (excessive formation of blood clots), impaired kidney function, neurological issues, and heart complications. Multiple mechanisms likely contribute to the variability in the immune response within the population and determine whether a person has asymptomatic disease, mild disease, or severe disease with potentially fatal complications. Increased understanding of the immune response to infection by the SARS-CoV-2 response will…...

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Nancy Gough Nancy R. Gough is the owner of BioSerendipity (www.bioserendipity.com). A Ph.D. scientist with a passion for scientific communication and incredible scientific curiosity, her scientific expertise spans basic research in the life sciences to translational medicine. After 17 years with the American Association for the Advancement of Science (AAAS), Dr. Gough stepped down as the Editor of Science Signaling (a weekly multidisciplinary journal) and launched her company. Through BioSerendipity, she serves as a scientific consultant for researchers, a consultant to scholarly publishers and scientific organizations, and a freelance writer and editor. She has a Ph.D. in Pharmacology and Experimental Therapeutics from the University of Maryland Medical School. After graduating, she joined Johns Hopkins University, first as a postdoctoral fellow, then as a research associate, in the lab of Dr. Douglas Fambrough in the Biology Department. She performed research in cell biology, as well as taught undergraduate and graduate courses.