Why We Invested in Arpeggio Bio — Making Safer And More Effective Medications

1 min read

Excited to announce our investment in Arpeggio Bio, which engineers drugs to change the transcriptome, with the goal of making safer and more effective medicine. The $17M series A is being led by Builders VC and includes also existing investors Khosla Ventures, TechU, FundersClub and new investors Tencent, Formic, ATEM, BoxOne and Matt De Silva. Tau Ventures is an AI-first fund in Silicon Valley investing primarily in seed and we occasionally take earlier or later bets when we see immense promise. We are also investing in US / Canada but in exceptional cases will consider a deal outside. Arpeggio was founded in 2018 in Boulder and impressed us with (1) a strong need, (2) building an execution-focused team, and (3) their long-term vision.

1) The Need

RNA is becoming the new platform, case in point the covid vaccine pioneered by Moderna and Pfizer. We see both Big Pharma (Merck, Roche etc) and New Pharma (Recursion, Gingko etc) needing these capabilities. There are also increasingly new startups that can benefit from Arpeggio’s tools, for instance Altos Labs notably raised $3B in its seed in Jan 2022. Below is a screenshot from one of their founding papers on non-coding RNAs and transcription.

2) The Team

We thought the cofounder’s backgrounds speak for themselves: https://www.linkedin.com/in/joeyazofeifa, https://www.linkedin.com/in/tim-read-a576b9b7, https://www.linkedin.com/in/laura-norris-056711159 and https://www.linkedin.com/in/robin-dowell-7886914. Joey and Tim met during their PhD at Prof Dowell’s Lab at the University of Colorado. Boulder has a strong ecosystem around life sciences which has helped them in hiring. The team is focused on translating research into therapeutics and their nascent-RNA sequencing technology has been leveraged by 40+ pharma companies like J&J, Pfizer, and Genentech.

3) Long-term Vision

Arpeggio has been able to reduce significantly the possibility of toxic side-effects – a very hard problem that is obviously an imperative for drugs. With the database linking drugs to their effect on nascent RNA, they have identified new small molecules treating mesenchymal tumors and autoimmunity.

We are honored and excited to be part of Arpeggio’s journey, using technology to solve a big problem. More at https://www.arpeggiobio.com.


Originally published on “Data Driven Investor,” am happy to syndicate on other platforms. I am the Managing Partner and Cofounder of Tau Ventures with 20 years in Silicon Valley across corporates, own startup, and VC funds. These are purposely short articles focused on practical insights (I call it gl;dr — good length; did read). Many of my writings are at https://www.linkedin.com/in/amgarg/detail/recent-activity/posts and I would be stoked if they get people interested enough in a topic to explore in further depth. If this article had useful insights for you comment away and/or give a like on the article and on the Tau Ventures’ LinkedIn page, with due thanks for supporting our work. All opinions expressed here are my own.

Amit Garg I have been in Silicon Valley for 20 years -- at Samsung NEXT Ventures, running my own startup (as of May 2019 a series D that has raised $120M and valued at $450M), at Norwest Ventures, and doing product and analytics at Google. My academic training is BS in computer science and MS in biomedical informatics, both from Stanford, and MBA from Harvard. I speak natively 3 languages, live carbon-neutral, am a 70.3 Ironman finisher, and have built a hospital in rural India serving 100,000 people.

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