Targeting the Imbalanced Immune Response in COVID-19

Too much histamine or prostaglandin D2 signaling or too little interferon signaling lead to increased risk for severe COVID-19. An imbalanced immune response appears to be the key to whether a person develops severe COVID-19 with pneumonia and other complications such as coagulopathy (excessive formation of blood clots), impaired kidney function, neurological issues, and heart complications. Multiple mechanisms likely contribute to the variability in the immune response within the population and determine whether a person has asymptomatic disease, mild disease, or severe disease with potentially fatal complications. Increased understanding of the immune response to infection by the SARS-CoV-2 response will…...