Neurobiology Reviews: Does the Brain Have Prediction-Error Neurons? NO

There is a recent paper in JNeurosci, Stimulus-specific prediction error neurons in mouse auditory cortex, where the authors stated that ‘Our data reveal that the auditory cortex learns to suppress responses to self-generated sounds along multiple acoustic dimensions simultaneously. We identify a distinct population of auditory cortex neurons that are not responsive to passive sounds or to the expected sound but that encode prediction errors. These prediction error neurons are abundant only in animals with a learned motor-sensory expectation, and encode one or two specific violations rather than a generic error signal. Together, these findings reveal that cortical predictions about…...